Unusual Presentation of Light Chain Deposition Disease:
A Case Report
Published: May 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/.7762
Disha Arora, Mayank Uppal, Vindu Amitabh, Usha Agrawal
1. Senior Resident, Department of Pathology, Safdarjung Hospital, New Delhi, India.
2. Ex- Senior Resident, Department of Medicine, Safdarjung Hospital, New Delhi, India.
3. Head of Department, Department of Nephrology, Safdarjung Hospital, New Delhi, India.
4. Scientist E, National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
Correspondence
Dr. Disha Arora,
House Number 6, Block Number 12, First Floor, West Patel Nagar, New Delhi – 110008 India.
E-mail: infinitely_disha@yahoo.com
Light Chain Deposition Disease (LCDD) is a rare disease characterized by deposition of monoclonal non-amyloid light chains in multiple organs. We report an unusual histologic manifestation of LCDD in a 55-year-old female patient, who presented with nephrotic syndrome and an increased serum creatinine. This case of LCDD had features of cast nephropathy on biopsy which is diagnostic of myeloma kidney, when the patient was clinically asymptomatic. Serum electrophoresis showed no abnormal band. There was no other evidence of a B-cell clonal disorder or amyloidosis. Following chemotherapy, improvement in renal function correlated with a reduction in circulating light-chain levels.
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